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Environ Sci Pollut Res 28(33):4535345363 Jiang M, Zhang J (2002) Water stress-induced abscisic acid accumulation triggers the increased generation of reactive oxygen species and up-regulates the activities of antioxidant enzymes in maize leaves

Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms

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Therefore, in future preclinical and clinical trials, the nephrotoxicity of small-molecule compounds will be a concern that requires specific attention

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